diff --git a/src/main.cpp b/src/main.cpp
index 9ee098d68..6a4caf330 100644
--- a/src/main.cpp
+++ b/src/main.cpp
@@ -67,7 +67,7 @@ Router *router = NULL; // Users of router don't care what sort of subclass imple
 // -----------------------------------------------------------------------------
 // Application
 // -----------------------------------------------------------------------------
-#if WIRE_INTERFACES_COUNT > 0
+#ifndef NO_WIRE
 void scanI2Cdevice(void)
 {
     byte err, addr;
@@ -364,7 +364,7 @@ void setup()
 
 #ifdef I2C_SDA
     Wire.begin(I2C_SDA, I2C_SCL);
-#elif WIRE_INTERFACES_COUNT > 0
+#elif !defined(NO_WIRE)
     Wire.begin();
 #endif
 
diff --git a/src/mesh/SX1262Interface.cpp b/src/mesh/SX1262Interface.cpp
index a99787475..7d4046731 100644
--- a/src/mesh/SX1262Interface.cpp
+++ b/src/mesh/SX1262Interface.cpp
@@ -34,7 +34,7 @@ bool SX1262Interface::init()
     pinMode(SX1262_TXEN, OUTPUT);
 #endif
 
-#if !defined(SX1262_E22) && !defined(SX1262_USE_DIO3_FOR_TCXO)
+#ifndef SX1262_E22
     float tcxoVoltage = 0; // None - we use an XTAL
 #else
     // Use DIO3 to power tcxo per https://github.com/jgromes/RadioLib/issues/12#issuecomment-520695575
diff --git a/src/nrf52/main-nrf52.cpp b/src/nrf52/main-nrf52.cpp
index b948d20a1..e5a4aadf7 100644
--- a/src/nrf52/main-nrf52.cpp
+++ b/src/nrf52/main-nrf52.cpp
@@ -155,7 +155,7 @@ void nrf52Setup() {
 void cpuDeepSleep(uint64_t msecToWake) {
   // FIXME, configure RTC or button press to wake us
   // FIXME, power down SPI, I2C, RAMs
-#if WIRE_INTERFACES_COUNT > 0
+#ifndef NO_WIRE
   Wire.end();
 #endif
   SPI.end();
diff --git a/variants/lora_isp4520/variant.h b/variants/lora_isp4520/variant.h
index fbc0b0d96..9bf5cd502 100644
--- a/variants/lora_isp4520/variant.h
+++ b/variants/lora_isp4520/variant.h
@@ -91,7 +91,9 @@
 #define BATTERY_PIN 3
 #define ADC_MULTIPLIER 1.436
 
-#define SX1262_USE_DIO3_FOR_TCXO
+#define SX1262_E22 // Not really an E22 but this board clones using DIO3 for tcxo control
+
+#define NO_WIRE
 #define NO_GPS
 #define NO_SCREEN
 #endif